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Lubert Stryer (born March 2, 1938, in Tianjin, China) is the Mrs. George A. Winzer Professor of Cell Biology, Emeritus, at the Stanford University School of Medicine.〔http://med.stanford.edu/profiles/Lubert_Stryer/〕〔http://www.amphilsoc.org/public-profile/C27D90EF-D697-DE11-A8C4-0013724C588C〕 His research over more than four decades has been centered on the interplay of light and life. In 2007 he received the National Medal of Science from President Bush at a ceremony at the White House for elucidating the biochemical basis of signal amplification in vision, pioneering the development of high density micro-arrays for genetic analysis, and authoring the standard undergraduate biochemistry textbook, ''Biochemistry''.〔http://www.nsf.gov/news/news_summ.jsp?cntn_id=109741〕 It is now in its eighth edition and also edited by Jeremy Berg, John L. Tymoczko and Gregory J. Gatto, Jr. Stryer received his B.S. degree from the University of Chicago in 1957 and his M.D. degree from Harvard Medical School. He was a Helen Hay Whitney Research Fellow〔http://www.hhwf.org/cgi/DirScript.cgi〕 in the Department of Physics at Harvard and then at the MRC Laboratory of Molecular Biology〔http://www2.mrc-lmb.cam.ac.uk/about-lmb/archiveservice/alumni/s〕 in Cambridge, England, before joining the faculty of the Department of Biochemistry at Stanford in 1963. In 1969 he moved to Yale to become Professor of Molecular Biophysics and Biochemistry, and in 1976, he returned to Stanford to head a new Department of Structural Biology.〔http://www.amphilsoc.org/public-profile/C27D90EF-D697-DE11-A8C4-0013724C588C〕 ==Research profile== Stryer and coworkers pioneered the use of fluorescence spectroscopy, particularly Förster resonance energy transfer (FRET), to monitor the structure and dynamics of biological macromolecules.〔Stryer, L., 1968. Fluorescence spectroscopy of proteins. ''Science'' 1632:526-533〕〔http://probes.invitrogen.com/resources/whatsnew/pressrelease/051302.html〕 In 1967, Stryer and Haugland showed that the efficiency of energy transfer depends on the inverse sixth power of the distance between the donor and acceptor,〔Stryer, L.,and Haugland, R.P., 1967. Energy transfer: a spectroscopic ruler. ''Proc. Natl. Acad. Sci. USA'' 58:719-725〕〔Lakowicz, J.R., 2006. ''Principles of Fluorescence Spectroscopy'' (Springer, 3rd ed., p. 449)〕 as predicted by Förster's theory. They proposed that energy transfer can serve as a spectroscopic ruler to reveal proximity relationships in biological macromolecules. A second contribution was Stryer's discovery of the primary stage of amplification in visual excitation.〔Fung,B., Hurley, J.B., and Stryer, L., 1981. Flow of information in the light-triggered cyclic nucleotide cascade of vision. ''Proc. Natl. Acad. Sci. USA '' 78:152-156〕〔http://pubs.acs.org/isubscribe/journals/cen/85/i29/html/8529awards.html〕 Stryer, together with Fung and Hurley, showed that a single photoexcited rhodopsin molecule activates many molecules of transducin, which in turn activate many molecules of a cyclic GMP phosphodiesterase. Stryer's laboratory has also contributed to our understanding of the role of calcium in visual recovery and adaptation.〔Koch, K.-W., and Stryer, L., 1988. Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ion. ''Nature'' 334:64-66〕〔 Starting in 1975, Stryer authored four editions of a textbook entitled ''Biochemistry''.〔Latchman,D.S. (1995) ''Trends Biochem. Sci.'' 20:488.〕 Stryer also chaired a National Research Council committee that produced a report entitled ''Bio2010: Transforming Undergraduate Education for Future Research Biologists''.〔http://www.nap.edu/catalog.php?record_id=10497〕〔http://www.ncbi.nlm.nih.gov/pmc/articles/PMC256982/〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Lubert Stryer」の詳細全文を読む スポンサード リンク
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